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Magnetic imaging instead of traditional PSA tests in prostate cancer screening would reduce problems with overdiagnosis, over-treatment of low-risk tumors and unnecessary cancers, according to a study by Karolinska Institutet.

In Sweden, national prostate cancer screening has not been introduced because current methods lead to overdiagnosis, leading to unnecessary multiple tissue samples. A new study conducted by Karolinska Institutet shows that magnetic resonance imaging (MRI) and target tissue samples can halve the number of cases of overdiagnosis.

– Our results from a large randomized study show that modern methods of prostate cancer screening retain the advantages of screening, while significantly reducing the disadvantages. This means that the biggest obstacle to the introduction of national screening has been removed, ” says Tobias Nordström, associate professor of urology at the Department of Clinical Sciences of Danderyd Hospital (ki DS) at Karolinska Institutet, responsible for the so-called sthlm3mr study. .

Early detection of prostate cancer

Prostate cancer is the most common cause of cancer deaths in men. In Sweden every year about 10 000 men suffer from prostate cancer, and 2500 die from this disease. Previous studies have shown that regular screening can lead to earlier detection and thus reduce the risk of death from prostate cancer.

National prostate cancer screening has not been introduced in Sweden because the current procedures – PSA tests combined with traditional tissue sampling – mean that many tissue samples are taken unnecessarily and a large number of harmless small tumours are detected. Therefore, the national health and welfare council assessed that national screening tests based on PSA (prostate-specific antigen) should not be carried out because the advantages do not outweigh the disadvantages. Currently, Lithuania is the only country in the world that has decided to introduce a nationwide screening program for prostate cancer.


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